Porous cellulose-collagen scaffolds for soft tissue regeneration: influence of cellulose derivatives on mechanical properties and compatibility with adipose-derived stem cells
نویسندگان
چکیده
This study compares two types of bioresorptive cellulose, i.e., calcium-sodium salt oxidized cellulose (OC) and sodium carboxymethylcellulose (CMC). It investigates which type would be preferable as an implant material in terms biocompatibility, biomechanical biological properties, also its behavior combination with collagen fibrils (Col) composite Col/OC or Col/CMC scaffolds. OC significantly supported the stiffness elasticity Col fibrils, whereas CMC reduced these properties. enabled a strong interaction even moist environment, accompanied by significant drop elastic modulus. The addition did not influence scaffold porosity; however, changes surface morphology lower swelling capacity OC, degree oxidation chains between 16 24%, idea improved cell-material interaction. guided human adipose-derived stem cells (hADSCs) to higher adhesion, proliferation, metabolic activity. On contrary, provided only limited mechanical support for inhibited their attachment although without any signs cytotoxicity. phenomenon could used future control differentiation hADSCs towards desired phenotype generate advanced tissue replacements using modern methods engineering. resulted firmer scaffolding material, required vascular skin is suitable wound healing, e.g. mucoadhesive gel, where cell adhesion desirable.
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ژورنال
عنوان ژورنال: Cellulose
سال: 2022
ISSN: ['1572-882X', '0969-0239']
DOI: https://doi.org/10.1007/s10570-022-04759-4